Below you will find all the synergistic ingredients found in ProVanax™ - each ingredient explaining exactly HOW and WHY it works on the human body.
We realize that the information is extensive, but we feel strongly that each client, member, and customer has the right to know exactly what they are putting in their bodies, why it works, and most importantly, how safe the products are - both for short and long-term usage.
Please remember that this product is patent pending and contains clinically proven ingredients in multiple University tested double-blind placebo-controlled trials. ProVanax™ also utilizes a Patented formulation extract to achieve these clinical results - US Patent #4,886,665.
|Ingredients||Amount Per Serving||%DV/RTI*|
|Magnesium Oxide||25 MGS||7%|
|Synergy Optimizer™ Technologies Blend||698 MGS||†|
5-HTP 5 Hydroxytryptophan (Griffonia Simplicifolia)
St. John's Wort (5% Hyperforin extract)
Passion Flower 10:1 Extract (Passiflora incarnate) (flower)
Valerian (4:1 extract)
GABA (Gamma-Amino-Butyric Acid)
Below you'll find detailed descriptions about the ingredients utilized in ProVanax™ - exactly HOW it works & WHY it's better than other products. To get started, simply click on the ingredients below and a detailed description will appear under it.
5-hydroxytryptophan (5-HTP) is an amino acid that occurs naturally in the body and is the final step in the production of the neurotransmitter serotonin, an important chemical that’s responsible for many of the brain impulses involving satisfaction and well being. 5-HTP is created through the hydroxylating of Tryptophan.
The body produces its own supply of 5-HTP from tryptophan, an amino acid found in high-protein foods such as chicken, fish, beef, and dairy products. Any healthy diet should include tryptophan-rich sources such as these. In addition, 5-HTP is available as a supplement; this form of the compound is extracted from the seeds of the African plant, Griffonia simplicifolia. Europeans have been taking 5-HTP for decades to treat insomnia and depression.
The diagram illustrates, simply, that 5-HTP is a more immediate precursor to serotonin than tryptophan is. This means 5-HTP is more directly linked to the production of serotonin than is tryptophan.
Numerous clinical trials have studied the efficacy of 5-HTP for treating depression. One compared 5-HTP to the antidepressant drug fluvoxamine and found 5-HTP to be equally effective.1 Researchers used the Hamilton Depression Rating Scale and a self-assessment scale to gauge the effectiveness of the two medications. Both scales revealed a gradual reduction in depressive symptoms through time with both medications.
Perhaps the most convincing evidence, however, comes from scientists who examined research from around the world on the use of 5-HTP in treating depression. One such researcher, writing in Neuropsychobiology, sums up the findings this way: "Of the 17 reviewed studies, 15 confirm that 5-HTP has true antidepressant properties."2
Researchers looking for other applications for 5-HTP found positive results in fibromyalgia treatment,6 weight loss in obese individuals7 and a reduction in occurrence of migraine headaches.8 Because so many conditions may be affected by serotonin function, it is not surprising to see such a wide range of therapeutic possibilities for 5-HTP.
It appears that 5-HTP may be one of the most helpful natural substances to be discovered in recent years. But, our own research has shown that higher dosages (especially when used by itself) only ends up causing an individual to be tired and "life-less". We have used a specific dose, to work in synergy with the other natural herbs and ingredients in ProVanax®, to allow one to feel relaxed, less anxiety and depression, WITHOUT feeling numb, tired and sedated!
St. John's Wort is a medicinal herb that has been used for centuries to treat depression. Its use for mild to moderate depression has been supported by clinical studies in recent years.
In Germany, where it is covered by health insurance as a prescription drug, some 35+ million people take 5-HTP (hypericum) for depression. A meta-analysis and review of 23 randomized clinical trials involving 1757 people with mild or moderately severe depressive disorders showed that St. John's Wort was 2.67 times superior to a placebo in relieving depressive symptoms and was as effective as standard antidepressant drugs.
Side effects occurred in 9.8% of patients on St. John's Wort, compared with 62.8% of those taking standard antidepressant drugs. The conclusion of the researchers was that St. John's Wort is more effective than a placebo for treatment of mild to moderately severe depressive disorders (Linde et al. 1996).
Most of the studies have examined the benefits of St. John's Wort in people with mild to moderate depression. However, Vorbach et al. (1997) compared 600 mg three times a day, a dosage double the usual prescribed dosage, with 50 mg three times a day of imipramine in patients with severe depression. St. John's Wort proved to be equivalent in efficacy, but with far fewer adverse effects (25.6%, compared to 81.4% for imipramine) (Vorbach et al. 1997).
One criticism of the St. John's Wort research was that, although the herb had compared favorably to drugs such as imipramine, amitriptyline, and maprotiline, it had yet to be compared to the more commonly prescribed selective serotonin reuptake inhibitors (SSRIs) such as Prozac. Three studies in patients with mild to moderate depression have changed that.
In the first study, Harrer et al. (1999) found 800 mg a day of St. John's Wort extract to be as effective in elderly German patients as Prozac.
In the second study by Schrader (2000), a rather low daily dose of St. John's Wort (500 mg a day) was equivalent to 20 mg a day of fluoxetine (Prozac). Significantly, more of the 240 volunteers responded to St. John's Wort than Prozac (60% versus 40%) and the herb produced significantly fewer side effects (8% of St. John's Wort patients versus 23% of Prozac patients).
In a 2000 study, the same low dose (500 mg a day) proved as effective as 75 mg twice a day of imipramine, but with far fewer side effects (Woelk 2000).
A third study by Brenner et al. (2000) judged St. John's Wort extract (600 mg for 1week, then 900 mg for 6 weeks) as beneficial as sertraline (Zoloft, 50 mg for 1 week, then 75 mg for 6 weeks).
Health practitioners have also found St. John's Wort helpful in treating low mood associated with menopause, premenstrual syndrome, and seasonal affective disorder (S.A.D.) Grube et al. (1999) gave menopausal women 300 mg three times daily of St. John's Wort for 12 weeks.
Surprisingly, both the psychological and physical symptoms of menopause improved substantially. So did sexual well-being. Kasper (1997) found that St. John's Wort decreased the low mood associated with seasonal affective disorder on par with results the same researcher had found earlier for fluoxetine (Prozac).
Another point of question is that the St. John's Wort extracts used in studies were standardized to an ingredient called hypericin. The process of standardization is for quality assurance. It is a guarantee that a specified amount of an ingredient (presumably the medicinally active ingredient) is present in the herbal extract. The PDR for Herbal Medicine, a respected herbal reference, states that hyperforin and not hypericin may be the primary active ingredient for treating depression.
In one study, patients received either placebo, a St. John's Wort extract standardized to 0.5% hyperforin, or a St. John's Wort extract standardized to 5% hyperforin. Only patients who received the extract of 5% hyperforin showed significant improvement of depressive symptoms (Laakman et al.). It is possible that in the JAMA study, the subjects receiving the St. John's Wort extract may have significantly improved if the extract had been standardized to hyperforin.
Passion Flower, whose genus name is passiflora, is a naturally grown medicinal herb, approved by the German Commission E in the treatment of insomnia and nervousness.
It is also used as a sedative in nervous disorders (including gastrointestinal complaints of nervous origin), difficulties in sleeping, and anxiety or restlessness. Passion Flower reduces spasms and depresses the central nervous system.
Passion flower has a tranquilizing effect, including mild sedative and anti-anxiety effects. In studies conducted since the 1930's, its mode of action has been found to be different than that of most sedative drugs (sleeping pills), thus making it a non-addictive herb to promote relaxation.
The sedative effect of Passion flower has made it popular for treating a variety of ailments, including nervousness and insomnia. Research had indicated that passion flower has a complex activity on the central nervous system (CNS), which is responsible for its overall tranquilizing effects. Also, it apparently has an antispasmodic effect on smooth muscles within the body, including the digestive system, promoting digestion.
But for sleeping purposes, a much higher dosage is required. In ProVanax, we use a lower dose, but a much higher quality extract in which you will receive all of the "anti-anxiety" benefits, but WITHOUT the sedation!
Valerian is a perennial plant native to North America and Europe. The root is the portion of the plant used for medicinal effects. Historically, valerian's primary use was as a sedative for the relief of insomnia, anxiety, mental stress and conditions associated with pain. Several recent clinical studies have substantiated this historical use.
Valerian appears to work by binding to or enhancing the effects of the same brain receptors as diazepam (Valium) and other benzodiazepine drugs (such as Xanax). However, Valerian appears to be MUCH BETTER tolerated, as side-effects such as impaired mental function, morning "hangover," and dependency, which are such a problem with benzodiazepines, have NOT been reported with valerian.
Traditional herbalists have used valerian as an anxiolytic, frequently in combination with other herbal preparations such as passion flower and St. John's wort (both ingredients found in ProVanax®).
In a recent preliminary, randomized, double-blind, placebo-controlled trial,16 36 patients with a diagnosis of generalized anxiety disorder were treated with placebo, diazepam in a dosage of 2.5 mg three times daily, or valerian extract in a dosage of 50 mg three times daily (80 percent dihydrovaltrate, 15 percent valtrate, and 5 percent acevaltrate; BYK-Gulden, Lomberg, Germany) for four weeks. Dosage was regulated at one week if an interviewing psychiatrist deemed an increase or decrease necessary.
Although the study was limited by a small number of patients in each group, relatively low dosages of the active agents, and a short duration of treatment, the authors found a significant reduction in the psychic factor of the Hamilton Anxiety Scale (HAM-A) with diazepam and valerian.
Another RCT17 compared 120 mg of kava (LI 150), 600 mg of valerian (LI 156), and placebo taken daily for seven days in relieving physiologic measures of stress induced under laboratory conditions in 54 healthy volunteers. Valerian and kava, but not placebo, significantly decreased systolic blood pressure responsivity, heart rate reaction, and self-reported stress. (note: "LI 156" is an identification number referring to the specific herb and the manufacturer; in this case, Lichtwer Pharma UK, Ltd.)
Inositol is an unofficial member of the B vitamin group that functions as a primary component of cell membranes. Although inositol has not been shown to be essential in the human diet, supplementation has shown to exert some very beneficial effects in cases of depression, panic attacks and even diabetes.
Inositol is required for the proper action of several brain neurotransmitters, including serotonin and acetylcholine. It is currently thought that a reduction of brain inositol levels may induce depression, as inositol levels in the cerebrospinal fluid have been shown to be low in patients with depression.
In double-blind studies, inositol has demonstrated therapeutic results (i.e. reduction in score of the Hamilton Depression Scale - HDS) similar to those of tricyclic antidepressant drugs - but WITHOUT the side effects.
Because of the effect of inositol on depression, a double-blind study was designed to test inositol's effectiveness in panic disorders. The frequency and severity of panic attacks declined significantly more after inositol, than after placebo administration.
Hundreds of studies exist showing the many health benefits of green tea. But what makes it the most consumed beverage in the world after water is its pleasant taste and relaxation effect. Both of these qualities—and more—can be traced to a unique, neurologically-active amino acid in tea called L-theanine (gamma-ethylamino-L-glutamic acid).
L-theanine is a free (non-protein) amino acid found almost exclusively in tea plants (Camellia sp.), constituting between 1 and 2-percent of the dry weight of tea leaves. It is the predominant amino acid in green tea leaves, giving tea its characteristic umami or "5th taste" (besides the four traditional tastes: sweet, salty, acid, and bitter).
ProVanax uses pure, decaffeinated Green Tea Extract with the highest 90% polyphenols; 45% EGCG. BUT, we've enhanced it with additional, NATURALLY OCCURING (not man-made) L-Theanine.
This combination makes it far more absorbable, because it comes in its NATURAL form - not processed - 100% organic!
Research on human volunteers has demonstrated that L-theanine creates a sense of relaxation in approximately 30-40 minutes after ingestion via at least two different mechanisms. First, this amino acid directly stimulates the production of alpha brain waves, creating a state of deep relaxation and mental alertness similar to what is achieved through meditation. (1) Second, L-theanine is involved in the formation of the inhibitory neurotransmitter, gamma amino butyric acid (GABA). GABA influences the levels of two other neurotransmitters, dopamine and serotonin, producing the key relaxation effect. (2)
Stress and anxiety are debilitating conditions that upset the balance of our hormones leading to a loss of our well-being, performance, and even life span. Stress impairs the immune system, leaving us vulnerable to opportunistic infections, and can cause depression. In 1998, pharmaceutical sales of anti-anxiety drugs totaled over 700 million dollars, while sales of antidepressants totaled close to 5 billion dollars!
People under stress can mitigate many of the harmful effects of stress with L-theanine without becoming sedated in the process. L-theanine doesn't make one drowsy, nor does it promote sleep because this amino acid does not produce theta waves in the brain.
L-theanine has a significant effect on the release or reduction of neurotransmitters like dopamine and serotonin, resulting in improved memory and learning ability. L-theanine may also influence emotions due to its effects on the increased release of dopamine. L-theanine reduces brain serotonin concentration by either curtailing serotonin synthesis or increasing degradation in the brain.
The regulation of blood pressure is partly dependent upon catecholaminergic and serotonergic neurons in both the brain and the peripheral nervous system. Studies on spontaneously hypertensive rats (SHR) showed an impressive blood pressure lowering effect with L-theanine. The lowered blood pressure effect was dose-dependent with the highest test dose creating the most significant drop.
l-Taurine is one of the first anti-anxiety amino acids that humans are exposed to since it comes to them in mother's milk. Combining l-Taurine with the relaxing mineral Magnesium makes a wonderful anti-anxiety solution.
When you are low on l-Taurine, you have probably been lacking in for a while, it may take weeks of supplementation until your reserves are filled up again. Without enough Magnesium you are going to feel tight and stressed and without sufficient l-Taurine you will feel anxious.
Taurine also helps relax blood vessels and is helpful for improving blood pressure and memory as well.
Magnesium is an often-overlooked nutrient. It is essential for hundreds of biological processes in the human body, but the majority of people do not consume an adequate amount, and few are aware of its importance. Magnesium is involved in over 300 biochemical processes in the human body, making adequate magnesium intake essential for health and vitality.
Magnesium aids in calming the nerves and relaxing the muscles. Low magnesium levels can also cause the release of certain stress hormones in the body, particularly high levels of norepinephrine, which increase under stress.
When a person feels stressed, hormones signal cells to release magnesium into the blood. From there, the mineral is excreted in urine. The more stressed a person becomes the more magnesium is lost from the body. Sleep deprivation itself is a chronic stressor that can lower magnesium levels.
GABA (gamma-aminobutyric acid) is an amino acid. It is the main inhibitory (calming) neurotransmitter in the brain. Neurotransmitters are chemical messengers between neurons (nerve cells).
Here's something interesting, most drugs that decrease anxiety - such as prescription tranquilizers, alcohol or marijuana - all work by increasing the neurotransmitter GABA, which is the brain's "peacemaker". GABA helps to turn off excess adrenalin and calms you down.
Having enough GABA in your brain is linked to being relaxed and happy. Having too little GABA is linked to the sleeping problem insomnia, and feeling anxious, stressed, tense and depressed.
When people are nervous or anxious their brains produce more beta brain waves than alpha brain waves. Taking GABA increases the amount of alpha waves. Alpha waves are linked to clear thinking, good focus and being in “the zone” or “the flow”. In these mind states, in which we are focused, calm and productive, we have high amounts of alpha brain wave activity.